The Marquette & Bessemer No. 2, a railroad car ferry that chugged daily between Conneaut and Port Stanley, Ontario, sank in a storm in December 1909.
The captain and crew of 35 died in the wreck. And the boat was never found.
You can research this story, and lots of stories from the Great Lakes at the Historical Collection of the Great Lakes, housed at Bowling Green State University in partnership with the National Museum of the Great Lakes in Toledo.